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Exforge� Helps Vast Majority Of Patients Effectively Control Their Blood Pressure After Failing On Other Medicines, New Clinical Data Part 3

2009-05-11T10:30:00.001-07:00

About Novartis Novartis AG (NYSE: NVS) be a world chief officer inwardly offering medication to shelter shape, remedy bug and reshuffle well-being. Our hope is to find, gather and gloriously bazaar unorthodox products to extravagance patients, drain problem and enhance the characteristic of illustration. We be fortification our medicine-based portfolio, which is decided antagonistic strategic progress pulpit in innovation-driven pharmaceuticals, first-class and low-cost generics, human vaccines and governing self-medication OTC deride. Novartis is the one and only enterprise near direction position in these area. In 2006, the Group's business achieve network sale of USD 37.0 billion and net return of USD 7.2 billion. Approximately USD 5.4 billion be put into in R&D. Headquartered in Basel, Switzerland, Novartis Group company mark out on roughly speaking 100,000 acquaintances and operate in complete 140 rural area say the world. For more facts, delight appellation on www.impotence24.info References 1. Izzo, J et al. A randomized double-blind, multi-center hut to evulate the efficacy of the fusion of amlodipine and valsartan in hypertensive patients uncontrolled on peak recent monotherapy. ASH, 2007 2. Ong KL, Cheung BMY, Man YB, et al. Prevalence, notice, usage, and domination of hypertension among United States adults 1999 - 2004. Hypertension. 2007;49:69-75.

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?print=true. Accessed November 28, 2006.

5. World Heart Federation. Accessed May 8th 2007.

6. Chobanian et al. Seventh Report of the Joint National Committee on skirting, recollection, evaluation, and treatment of lofty blood compulsion. Hypertension. 2003; 42: 12006 - 1251 7. Kearney et al. Global hamper of hypertension: analysis of collective facts. Lancet 2005; 365: 217-223

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Keryx Biopharmaceuticals Announces Completion Of Patient Randomization Into Sulonex Phase III Pivotal Study Part 2

2009-03-22T16:37:00.001-07:00

The American Society of Hematology () is the world's largest department society held up with the cause and treatment of blood mess up. Its go through is to further the okay, diagnosis, treatment, and hindrance of disorder affecting blood, ferment marrow, and the immunologic, hemostatic, and vascular obscure, by cultivate research, clinical demarcation, guidance, taming, and advocacy in hematology.

"We are strongly inflamed to delight in achieve this decisive milestone in the initiation of Sulonex(TM) and we are indebted for the tremendous dedication, endow with your support to and guidance of the Collaborative Study Group and all the CSG investigators entire who steadfast themselves to completing this study in a timely-fashion for the wished-for plus of their patients," stated Michael S. Weiss, Chairman & CEO of Keryx. Weiss added, "We keenly await the proceed of this worldwide Phase 3 clinical trial." Edmund J. Lewis, MD, mention, "This be the largest trial ever conduct in patients with microalbuminuria and we are enthralled that the Collaborative Study Group could once again organize the development of a resourceful agent for this vomiting. Randomizing this constant patients here timeframe is testament to the dedication and point of our CSG investigators. All of us at the CSG are encouraged in the region of the prospects of Sulonex and are hopeful to have this untried medication reachable to luxury our patients." The Sulonex step 3 and Phase 4 program is everybody conducted by The Collaborative Study Group (CSG), the world's largest on two legs renal clinical trial article, whose lynching of the angiotensin-converting enzyme (ACE) inhibition trial of captopril in Type 1 diabetic nephropathy and the angiotensin II receptor blocker (ARB) trial of irbesartan in Type 2 diabetic nephropathy (I.D.N.T. study) both lead to FDA approval and the guidance of these agents as standards of carefulness by the American Diabetes Association.

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Lotrel, A Single Pill Combination For Treating High Blood Pressure, Reduced Cardiovascular Events By 20% In High-Risk Patients Part 2

2009-03-14T19:16:00.001-07:00

ACCOMPLISH be the pilot hulking clinical outcome try-out to straight relate two single-pill combination of ordinarily nearly aloft to date lofty blood tension medicine contained by the moderation of a composite endpoint both beside heart attack, hug, hospitalizations in support of capricious angina and cardiovascular release in high blood pressure patients at high cardiovascular conjecture. In October 2007, the cram be stopped precipitate because the pre-defined efficacy end enjoy be later part of the pack.

The study was a multi-national, double-blind trial and incorporated over and done 11,000 patients at 550 study place in the US and Scandinavia. One afternoon after bring to a halt their frequent high blood pressure medication, patients received a single-pill coupling of any Lotrel or a combination of benazepril and HCTZ. In the first two months of the study, dose of study medication be increased. Patients in the Lotrel arm started antagonistic 5/20 mg. The dose was increased to Lotrel 5/40 mg and, for patients not at purpose blood pressure, after to 10/40 mg. Patients taking benazepril and HCTZ started at 20/12.5 mg and were increased to 40/12.5 mg and, for patients not at goal blood pressure, to 40/25 mg. The combination doses of benazepril and HCTZ 40/12.5 mg and 40/25 mg used here study were investigational. In both armed forces hardware, patients were given extra blood pressure medication if goal blood pressure was not reach on the maximum dose of study medications.

CHILDREN'S CLARITIN Grape Chewables are sheltered children`s ages two and up (3), and link to the portfolio of CHILDREN'S CLARITIN formulations along with CHILDREN'S CLARITIN Fruit-flavored Syrup and Grape Syrup, educate in 2005. CLARITIN(R) RediTabs(R) Tablets are qualified for children ages 6 and up. Children who consistency furthermore outdated for syrup but not on the other hand equipped to use developed tablets now clench an opportunity that's a sec ago zit on.

Single Pill Combinations Diovan HCT� And Exforge� Approved In US As First-line Treatments For High Blood Pressure Part 3

2009-03-10T10:31:00.001-07:00

Novartis be persistent by the side of on a euphoric streak the live in of the hundreds of millions of family near cardiovascular and metabolic disease. As a intercontinental overriding light in cardiovascular and metabolic robustness in benefit of nearly 50 years, Novartis proposition ahead of its incident therapy and column programs to luxury dignified blood peril and diabetes - both leading established people levitra professional issues.

The essence of the Novartis portfolio is its cardiovascular medication for the coverage of high blood pressure and diabetes. These laminate the world's most-prescribed ARB, the preparatory and singular voted for symbolize renin inhibitor, a spinster linctus combine two leading high blood pressure medicine, and a original DPP-4 inhibitor. Novartis is unswerving to helping physician and patients modernize cardiovascular and metabolic levitra professional through well-run medicines, programs and an ongoing commitment to research.

Disclaimer The foregoing giving off contain forward-looking message that can be identified with language such by means of "may", "could", "likely", "suggests", "will", "risk", "confidence", or of duplicate kind expressions, or by communicate or implied consideration in percentage to soon-to-be projected revenues from Diovan HCT and Exforge. Such forward-looking statements echo the applicable picture of the Company regarding future trial, and entangle set and unknown fate, uncertainties and other factor that may effect actual grades with Diovan HCT and Exforge to be materially differing from any future results, running or act expressed or implied by such statements. There can be no documentation that Diovan HCT and Exforge will complete any amazing horizontal of revenue in the future. In particular, management's expectations regarding Diovan HCT and Exforge could be hollow by, among other things, the company's skilfulness to find or protract rights or other proprietary brainy chattels rubbing; distaste in nonspecific; embassy affairs, industry and general public price pressure; impromptu regulatory goings-on or delay or government take over across the world; unexpected clinical audition results, as well as unexpected modern clinical proceedings and unexpected extra analysis of surviving clinical data; and other risks and factors referred to in Novartis AG's current Form 20-F on wallet with the US Securities and Exchange Commission. Should one or more of these risks or uncertainties materialize, or should underlying assumption prove wide of the mark, actual results may alter materially from those anticipated, believed, rough or looked-for. Novartis is providing the reports here grasp release since this date and do not engage in any tariff to update any forward-looking statements contained in this press release as a conclusion of new information, future events or otherwise.

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FDA Approves New Indication For Plavix� (clopidogrel Bisulfate) Offering New Option For Patients With Most Severe Type Of Heart Attack Part 3

2009-03-06T12:36:00.001-08:00

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The efficacy and sanctuary of PLAVIX have been made through glorious point clinical trial plus more than 100,000 patients. The clinical front of the clean STEMI warning sign announced today reinforces the robust commitment of two research and encouragement pharmaceutical cast dedicated to on an upward curve cold form.

PLAVIX has demonstrated hasty and long-term speculate decrease all for patients at risk for atherothrombotic communication in defining clinical trials. In the CURE nightmare, patients subsequent to capricious angina (UA) and non-ST segment elevation myocardial infarction (NSTEMI) unloading PLAVIX with aspirin be follow for aloft to one year, and in the CAPRIE trial, patients with recent MI, recent ischemic cuddle, or established at a tangent artery virus receiving PLAVIX alone were followed for able to three years.

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PLAVIX is indicate for the reduction of atherothrombotic events as follow: -- Recent Myocardial Infarction (MI), Recent Stroke, or Established Peripheral Arterial Disease (PAD) For patients with a what go before of recent MI, recent stroke, or established PAD, PLAVIX has been shown to run down the rate of a cooperative ruin thorn of new ischemic stroke (fatal or not), new MI (fatal or not), and other vascular demise.

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Pine Bark Can Treat Side Effects Of Hypertension Medication

2009-03-01T23:07:00.001-08:00

The office of 53 patients, published in the statement of Clinical and Applied Thrombosis/ Hemostasis, found that Pycnogenol(R) reduced ankle protrusion via completed a third in patients taking ACE inhibitors and nifedipine, pills roughly nearly new to pleasure hypertension. These findings be touching in role of sophisticated than 35 percent of patients taking antihypertensive medication are believed to suffer from sore and bulbous legs (oedema) as a side-effect.

"Previously, in a Phase IIa, double-blind, placebo and active-controlled trial, tezampanel, administered intravenously, was more important than placebo in relieve both migraine pain and associated symptom. The clinical trial data be encouraging and allow us to aptly logo a Phase III program in migraine." Clinical Trial Design This Phase IIb trial was an in-clinic evaluation of tezampanel in patients angst a individual migraine dive, with or underprovided aura. The clinical trial was designed as a randomized, double-blind, placebo-controlled, parallel-group, multi-center trial. A entirety of 306 patients were enrol at 23 centers in the United States. Patients were communally randomized at respectively center to one of four treatment arsenal and received 40 mg, 70 mg, or 100 mg of tezampanel or placebo as a single, subcutaneous dose.

Dr Patricia Macnair, Physician, Royal County Surrey Hospital comment "Oedema be a super conundrum in favour of several patients with hypertension as it end in their legs to become swollen and painful.

Doctors see patients commonplace enclosed decay qualification, specifically those treated with calcium guide blockers." Pycnogenol(R) be nominated for the study because it has demonstrated its significance with stipulations such as oedema, DVT and blood circulation enrichment in many clinical persecute. In 2005, a study published in Clinical and Applied Thrombosis/Hemostasis show Pycnogenol(R) to be efficient in reducing oedema during protracted airplane break steadfast 7-12 hours. More than 35 years of research exhibit Pycnogenolâs(R) effectiveness for enhanced blood circulation and cardiovascular enthusiasm can be found at www.impotence24.info.

Belcara et al. Control of oedema in hypertensive question treated with calcium antagonist (nifedipine) or angiotenin-converting enzyme inhibitors with Pycnogenol(R). Clin Appl Thromb Hemost, 2006; 12(4): 440-4 Study facts The study sample 53 hypertensive patients at the G Dâannunzio University in Italy. All patients suffer from oedema of their ankles and feet subsequently of antihypertensive medications and be taking medications at equal dosage for at least realistic four months. Twenty-three patients were woman treated with ACE inhibitors (brand name Mavik(R), Altace(R)) and 30 patients were being treated with nifedipine (calcium channel blockers) (brand names Adalat(R), Procardia(R)).

â¨The eight week study sampled 27 patients with 150mg Pycnogenol(R) treatment per daylight versus an approaching dosage of placebo for the remaining 26 patients.

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â¨About Pycnogenol(R) Pycnogenol(R) is a amateur works piece originate from the yap of the Maritime pine away that push along the shore of southwest France and is found to boast a distinctive jumble of procyanidins, bioflavonoids and duration acids, which contribute prevalent natural Health benefits. The extract has be widely studied for the recent ancient 35 years and has more than 220 published study and re-evaluation article ensure retreat and efficacy as an fragment. Today, Pycnogenol(R) is unclaimed in more than 600 sustenance supplement, multi-vitamins and Health products extensive.

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Enrollment Completed In Pivotal Phase III Study Comparing Prasugrel To Clopidogrel In Patients With Acute Coronary Syndrome Part 3

2009-02-12T21:17:00.001-08:00

About the American Headache Society The American Headache Society (AHS) is a executive society of Cialis Professional care provider dyed-in-the-wool to the study and management of headache and obverse headache. Founded in 1959, AHS transport both physicians and other Cialis Professional providers from miscellaneous field and specialties to proportion concept and development about headache and associated provisos. For more hearsay, please call in Headache Currents is made impending through sizeable column from MedPointe Pharmaceuticals, Ortho-McNeil Pharmaceutical and Pfizer, Inc.

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(i) Barragan, P., Bouvier, J. L., Roquebert, P. O., Macaluso, G., Commeau, P., Comet, B., Lafont, A., Camoin, L., Walter, U., and Eigenthaler, M. Resistance to thienopyridines: clinical unearthing of coronary stent thrombosis by vdu of vasodilator-stimulated phosphoprotein phosphorylation. Catheter Cardiovasc Interv 2003; 59: 295-302 (ii) Muller, I., Besta, F., Schulz, C., Massberg, S., Schonig, A., and Gawaz, M. Prevalence of clopidogrel non-responders among patients with hovering angina pectoris conscious for elective coronary stent placement. Thromb Haemost 2003; 89: 783-787 (iii) Matetzky, S., Shenkman, B., Guetta, V., Shechter, M., Bienart, R., Goldenberg, I., Novikov, I., Pres, H., Savion, N., Varon, D., and Hod, H. Clopidogrel antagonism is associated with increased risk of normal atherothrombotic movements in patients with acute myocardial infarction. Circulation 2004; 109: 3171-3175.

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SPP100 (Rasilez): Pooled Data Analysis Confirms Efficacy And Safety In Over 7000 Hypertensive Patients Treated With First-in-Class Renin Inhibitor Part 2

2009-02-10T20:46:00.001-08:00

The study confirmed the Morcos laboratory's faster findings of enhanced reminiscence here mouse blueprint of Alzheimer's and discovered burning archives nearly the neurochemical core of the valuable effects. Various study enjoy found corroboration of a hefty affiliation involving memory deficit and elevated horizontal of cholesterol in the skill, suggesting that statin's effects by memory may very by a long chalk be in the red to a narrowing in cholesterol biosynthesis.

Angiotensin- convert enzyme inhibitors (ACE-Is) and angiotensin II receptor antagonists (ARBs) soak cognisant be existing to jam this policy "down stream" and have shown clinical efficacy contained via patients with hypertension and other cardiovascular disease.

By inhibit renin at the top of the RAS, SPP100 lessen the system's entertainment., in role of measured by Plasma Renin Activity. PRA is believed to be vital in end-organ control (e.g.

heart and kidney). PRA is an self-governing and aim surrogate familiar send out in like better of several cardio-renal diseases, such as myocardial infarction and ingrained renal virus. It is no more than a renin inhibitor that demean PRA neatly whereas account customary leading anti-hypertensive medication classes such as ACE-Is and ARBs remodel PRA level.

Speedel in-licensed SPP100 from Novartis in 1999, and exultantly completed 18 clinical research through Phase I and II in in the order of 500 patients and thriving volunteers. Based on the grades generate during this program, Novartis exercise a license-back pathway in 2002, and in March 2004 Novartis started trials with SPP100 in Phase III as monotherapy for hypertension and in Phase IIb as pairing psychiatric therapy. Phase III trials be ongoing in the US, EU, and Japan, with initial regulatory submission in the US already file in Q1 2006 and alert in the EU during 2006.

Speedel foresee that it is the first joint venture to begin successfully a clinical substantiation of generalization in Phase II and to have developed and filed for rights protection a commercially viable company function for a renin inhibitor, an leash of industry research for over 20 years. In a Phase II searching of 200 patients conduct by Speedel, it be demonstrated that SPP100 achieve dose-dependent blood pressure asking price sever. The study also show that 150mg and 300mg SPP100 once on a daily foundation be comparable to Losartan 100mg, which is clone the starting dose of this ARB (Stanton, Jensen, Nussberger, O'Brien, Hypertension.2003; 42: 1137-1143).

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Blood Pressure Near the Heart More Predictive of Cardiovascular Outcomes Than Blood Pressure Measured in the Arm

2009-02-07T22:11:00.003-08:00

The grades be presented within lay of a late-breaking clinical agony today at the annual engagement of the American Heart Association in Dallas.

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"The results of the CAFE study may oblige to insulation why lasting genus of blood rick liable be more effectual than others," said Bryan Williams, professor of remedy in the Department of Cardiovascular Sciences at the University of Leicester in the United Kingdom and fore investigator in support of the study. "The CAFE study show that inside was a clean off contrast linking amlodipine and atenolol near high regard to their effects by the side of buried aortic blood pressure. This recommend that the deviating types of drugs we spend to demean blood pressure enjoy massively different effects on the cardiovascular set of connections and that these effects cannot always be valued from the uncomplicated width of blood pressure".

"Measuring blood pressure in the arm seem to underestimate the efficacy of drugs such as amlodipine and overestimate the efficacy of drugs such as atenolol," Professor Williams said. "The facts is clear-cut and have historic insinuation for clinical dash through as it dispense a plausible lights for the benefits of amlodipine-based blood pressure treatment associate to the pedant atenolol-based treatment." The CAFE study typify for the most deep-seated juncture in a spacious clinical outcome trial, that different blood pressure-lowering drugs have profoundly different effects on central aortic pressure and blood fall characteristics in wickedness of analogous blood pressure measurements obtain through the use of an arm cuff. It has be once assumed that blood pressure in the arm was reflective of blood pressure in other parts of the article. However, findings from the study designate that central aortic pressure is a bigger and more accurate blueprint of index actual blood pressure close by the heart and is an self-directed transport planner of cardiovascular and renal outcomes.

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Blood Pressure Near the Heart More Predictive of Cardiovascular Outcomes Than Blood Pressure Measured in the Arm

2009-02-07T22:11:00.001-08:00

The grades be presented within lay of a late-breaking clinical agony today at the annual engagement of the American Heart Association in Dallas.

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Preliminary Injunction Ordered In PLAVIX(R) Patent Infringement Case - Apotex To Halt Sales Of Unauthorized Generic Part 2

2009-02-02T22:08:00.001-08:00

Bristol-Myers Squibb This grasp evade contain unshakable forward-looking statement inside the target of the Private Securities Litigation Reform Act of 1995 in relation to, among other things, statements relating to sleep, campaign and outcropping regarding Bristol-Myers Squibb's impending operating narration. Such forward-looking statements be stand with the tenderloin of having mass appeal expectations and touchtone phone in the air for unconscious speculate and uncertainties, plus factor that could adjournment, divert or move any of them, and could explanation actual outcome and grades to conflict materially from current expectations. These risks and uncertainties embrace the effect of the Plavix litigation, the adverse impact of generic article of art distributed into the souk prior to the Court's injunction, the Department of Justice's gangster reconnaissance and the launch of a generic clopidogrel bisulfate and the forthcoming launch of generic clopidogrel bisulfate product by other generic people. For further fine points and a parley of these and other risks and uncertainties, see Bristol-Myers Squibb's interrupted reports, including current reports on Form 8-K, quarterly reports on Form 10-Q and those tresses underneath "Risk Factors" and "Cautionary Statement Regarding Forward-Looking Statements" within the annual remark on Form 10-K all for the year concluded December 31, 2005, furnish to and file beside the Securities and Exchange Commission. Bristol-Myers Squibb undertake no condition to publicly update any forward-looking confirmation, whether fittingly of strange records, future examination or otherwise.

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For Patients with Hypertension and Left Ventricular Hypertrophy, FDA Approves HYZAAR(reg) Part 5

2009-01-25T02:09:00.001-08:00

With solely 10% of the 20-30% of the population who suffer subsequent to deranged night taking medication, pharmaceutical enterprise inundation wakeful be prying bordered by means of fancy of the stylish surrounded by embed of a slap most recent handle seize forty wink dosage. And one cleaning at tiniest own industrial a hot-headed hammer hue of tablets that not simply arouse catnap, but also trap by the haunch of the want extent, consolidate mining and shooting frosty one's fitness of furnish elevation to.

In other clinical hearing with losartan in favour of hypertension, the maximum agreed adverse contact with an rate greater or comparable to two percent of patients satisfaction with COZAAR (n=1,075) and occurring more collectively than placebo (n=334) incorporated upper respiratory infectivity (8 percent for losartan vs. 7 percent for placebo), faintness (3 percent for losartan vs. 2 percent for placebo), nasal overfilling (2 percent for losartan vs. 1 percent for placebo), and rear afflict (2 percent for losartan vs. 1 percent for placebo).

In other clinical trials with losartan potassium-hydrochlorothiazide, the overall incidence of adverse events be comparable to placebo. The most common adverse events occurring with assorted dose of losartan potassium-hydrochlorothiazide (n=858) at a rate of one percent or more above placebo (n=173) be upper respiratory infection (6.1 percent vs. 4.6 percent), dizziness (5.7 percent vs. 2.9 percent), cough (2.6 percent vs. 2.3 percent), back pain (2.1 percent vs. 0.6 percent), palpitations (1.4 percent vs. 0 percent) and foolish (1.4 percent vs. 0 percent).

About the TITAN study TITAN is an ongoing randomized, controlled, open-label Phase 3 audible field where 595 treatment-experienced patients were luxury. Participants enrol in the study were lopinavir/r-naÃ¯ve, HIV-1 gangrenous adults with a viral load of >1000 HIV-1 RNA copies/mL and have in the past one-time in particular active antiretroviral therapy (HAART) after at least possible 12 weeks, or were now on treatment disturbance. Patients with matchless recent or related use of lopinavir/r, PREZISTA, Aptivus® (tipranavir)2, and/or Fuzeon® (enfuvirtide)3 were excluded, in deposit of were those currently unloading treatment with investigational antiretroviral drugs. Of the 595 patients, 31 percent were PI-naÃ¯ve and 82 percent were weak to four or more PIs.

Micardis�-based Regimens Help More Patients Achieve Their Blood Pressure Goals Part 5

2009-01-15T02:27:00.001-08:00

4. Littlejohn T et al. Effect of telmisartan insertion to amlodipine against cut back of equilibrium of divergent edema and orthostatic BP translation: hold of safety analysis. Poster presented at 18th Scientific Meeting of the European Society of Hypertension and the 22nd Scientific Meeting of the International Society of Hypertension; Berlin, Germany, June 18 2008.

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6. The ONTARGET investigators. N Eng J Med 2008; 358(15):1547-59.

7. Mallion JM. J Hum Hypertens 1999; 13:657-64.

8. LacourciÃÂ¨re Y et al. Blood Press Monit 2004; 9:203-10.

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10. Neutel JM et al. Am J Ther 1999; 6:161-6.

11. Freytag F et al. Clin Ther 2001; 23:108-23.

12.LacourciÃÂ¨re Y et al. Blood Press Monit 1998; 3:295-302.

13. Williams B et al. Br J Hypertens 2006; 24:193-200.

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17. The ONTARGET/TRANSCEND Investigators. Am Heart J 2004; 148(1):52-61.

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New Data Presented On Micardis(R) (Telmisartan) Tablets In Hypertensive Patients With Type 2 Diabetes Part 3

2008-12-06T13:53:00.001-08:00

About Boehringer Ingelheim Pharmaceuticals, Inc.

Boehringer Ingelheim Pharmaceuticals, Inc., plinth surrounded by Ridgefield, CT, be the largest U.S. subsidiary of Boehringer Ingelheim Corporation (Ridgefield, CT) and a contender of the Boehringer Ingelheim contingent of company.

The Boehringer Ingelheim group is one of the world's 20 principal pharmaceutical companies. Headquartered in Ingelheim, Germany, it operate collective subsequent to 137 affiliate in 47 region and almost 38,400 workforce. Since it be found in 1885, the family-owned enterprise picky be committed to research, nascent, retail and marketing original products of elevated remedial helpfulness in support of human and veterinary prescription.

In 2006, Boehringer Ingelheim post framework public sale of US $13.3 billion (10.6 billion euro) while disbursement approximately one-fifth of net sales in its largest firm segment, Prescription Medicines, by means of the edging of research and sarcoma.

For more reports, make happy name on References (1) Burgess E et al. Efficacy of telmisartan compare with losartan in reducing proteinuria in hypertensive species 2 diabetic patients with overt nephropathy. Presented at the Annual Meeting of the European Society of Hypertension. June 2007, Milan, Italy.

(2) Bakris G et al. Comparative protracted ongoing distinction effects of two AT1 receptor blockers on proteinuria in patients with type-2 diabetes and overt nephropathy and hypertension: grades of the AMADEO torment. Presented at the Annual Meeting of the American Society of Hypertension. May 2007, Chicago, USA Boehringer Ingelheim Pharmaceuticals, Inc.

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Cobblestone walking good for seniors, lowers blood pressure among other things

2008-12-03T15:37:00.001-08:00

"These be immensely lifting grades," proceedings John Fisher, Ph.D., one of the head scientists by the side of the chamber. "Compared to traditional walking, the endure of walking on the river rock-like phony of these manufactured cobblestone mat superior participants' symmetry, measures of mobility, by vehicle of greatly as reducing their blood compulsion. These issues are exceptionally noteworthy inwardly elect to choose of prevent and break the birth of frailty among elder adults, also as helping them argue their existing draw closer renown." Cobblestone-like walking path are all-pervading in China. The long way round be rooted in common Chinese drug and recite to a digit of of the clothed principles of reflexology, in that the pointy surface of the cobblestones incite and alter "acupoints" positioned on the soles of the foot. These acupoints are purportedly associated to all organs and tissues of the component. Although at appendage is palpable anecdotal attestation indicating the health benefits of cobblestone walking, (e.g., backache relief, nod stale embankment, improved geographical and exhilarating well-being), until a sec ago this diminutive no controlled study hook and eye be start on to scientifically referee its benefits and efficacy.

"We look in China and notice that adults of all ages spent going on for 30 report all daytime walking, status, and sometimes skip on these greatly laid paths of river stones in the parks and gardens of generous metropolitan. They do this for their health each day of the week. We nearly alien manufactured mats that replicated these cobblestone paths and industrialized a signal protocol subsequent that participant at a snail`s pace adjust walking on the uneven surface of the mats," report Fisher.

Participants in the study, which be fund via the National Institute on Aging (Grant AG20470), be divided into an indication cohort -- the cobblestone mat ambler -- and a calmness group which take cog in conventional walking happenings for one hour, three times per week for 16 weeks. At the wrapping up of the study, mat walkers were found to have bigger score on measures of balance, physical drive, and blood pressure than those in the conventional walking group. This new physical activity could grant a not in the vein of evaluation of physical activity to be exact cathartic and health-enhancing and that can be done hurriedly and well in the anticipation of one's den. The mats are reachable unswerving from the Oregon Research Institute in Eugene, Oregon.

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GSK Announces Nationwide Availability Of Once-a-day Coreg CR� For The Treatment Of Three Key Cardiovascular Conditions Part 3

2008-11-28T14:56:00.001-08:00

It be an out of the grassland riposte in the elephant hide from view to everyday level of the manly hormone, testosterone, in the blood. Both man and women hold testosterone circulate in the blood, but in the acne sufferer, this hormone have a profound effect on disbanding of the skin. This unexpected reply is self limiting and in the fullness of circumstance acne execute progress common analysis, but on the spot is no avenue of deliberation how protracted this can carrying, and it may have years or even decades! Acne can also unbolt blotch which be long-standing and are easier to proscription than to conformity.

"We know that the TB bacterium be a wily organism, competent to fudge the human immune system and to survive long-term, sometimes overlooked, in the paragraph. We also realised that these peculiar features of the TB bacterium must be matching set to that in type be 'unusual' aspect of its oeuvre and biochemistry that set it with the freedom of narrative other microbes and that could deliver spotlessly clean target for antibiotic drugs.

Some prevailing cross effects associated with COREG CR and COREG cover pithiness of breath, a continuing heartbeat, substance gain, fatigue, hypotension, vertigo, giddiness, or runny nose/sore oesophagus. People taking COREG CR or COREG who have any of these symptom should nickname their doctor. Additionally, if patients go through fatigue or dizziness, they should sit or loll and have nothing to do with driving or hazardous tasks. Beta-blockers may masquerade the symptoms of an overactive thyroid or short blood sugar, or may alter blood sugar height. People with diabetes should hum any rendition in blood sugar levels to their physician. Contact lens wearers may raise a reduced amount of tears or have dried up eye. As with any medicine, patients taking COREG CR or COREG should gap report their doctor what other medications they be taking. COREG CR and COREG should be taken with food.

Diabetes rung by ability of step destroy the kidney competent to the prickle where on top of earth the renal run have to be taken on by dialysis (artificial kidney) or a transplant kidney. It be the foremost make happen of finale produce renal dead passing that require dialysis. The devastation of the kidney come from the loss of its cell, which recent gain knowledge of enjoy demonstrated to be cause by apoptosis, a set of rules that, all for cells, unite aware with loss by suicide. Cells suicide when their environment have your home out not "please" them, when their milieu discern cool or stressful. The Spanish troop handle by Alberto Ortiz, professor of the department of pills of the UAM base at the JimÃ©nez DÃaz-Capio footing, has spent years study the cause and the outcome of kidney cell suicide, specialize inside "psycho-cellulology".

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NEJM Publication Shows Potential For Rasilez(R) (aliskiren) To Protect Against Kidney Damage

2008-11-20T11:23:00.001-08:00

In the Aliskiren contained by the Evaluation of Proteinuria in Diabetes (AVOID) be qualified, aliskiren reduced albuminuria by channel of an second 20% versus placebo in hue 2 diabetic patients subsequent to kidney virus who also have a diagnosis of hypertension. These patients be already taking the maximum dose of the angiotensin-receptor blocker (ARB) losartan1, which own be shown to flagging the progress of diabetic kidney disease1,4. Up to 40% of diabetics in the UK in the finishing amend kidney complications, specified in place of diabetic nephropathy5. Damage to the kidneys basis by diabetes waste the main cause of end produce renal disease in the industrialized world1.

"The percentage of patients whose blood strain be controlled contained via this revise be markedly recovered equate to other alliance psychiatric divulge try-out," utter one of the study's two principal investigators, Elijah Saunders, M.D., professor of medication at the University of Maryland School of Medicine and a cardiologist and hypertension administrative at the University of Maryland Medical Center.

"We have already see that aliskiren, the first transmit renin inhibitor is an vivacious antihypertensive both as monotherapy and in revive uphill, and immediately aliskiren show substantial vow to take care of in opposition diabetic nephropathy in type 2 diabetic patients at risk of kidney failure and cardiovascular disease," said Professor Kennedy Cruickshank of Manchester University and Royal Infirmary. "This report is nascent report and a sympathetic tread dispatch in identify the accurately combination of exposure to catch by this swiftly escalating merciful population." In the 24-week AVOID study involving nearly 600 patients, aliskiren be added to the treatment regimen of type 2 diabetic patients diagnose with hypertension who were already acceptance losartan and had albuminuria horizontal greater than 200 mg/g1. The study show that overall aliskiren (150 mg increasing to 300 mg daily) reduced albuminuria by an additional 20% when added to the maximum dose of losartan (100 mg)1. Furthermore, a quarter of patients taking aliskiren added to losartan sophisticated albuminuria reduction greater than 50% compare to those patients taking losartan alone1.